WBC Image Atlas

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24- Fetus like Nucleus of Neutrophils in COVID19


C-shaped, fetus-like nuclei were noted in some COVID19 positive patients with aberrant nuclear projections, which we named as COVID nuclei.Recommended Further Readings: https://casereports.bmj.com/content/bmjcr/13/5/e236117.full.pdf
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23- Pseudo-Pelger-Huët hypogranular neutrophil


Pseudo-Pelger-Huët hypogranular neutrophil in a female patient with MDS. Some neutrophils show Barr body, a small darkly-stained nuclear spot (represents the female inactivate X chromosome)".

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22- Plasma cell versus osteoblast


Osteoblasts : eccentric nucleus protrudes from the cytoplasm Plasma cell : the nucleus contained within the cytoplasm.
Osteoblasts are cells which are similar in appearance but somewhat larger than plasma cells... The "hoff" area is sometimes located away from the nucleus. The cytoplasm appears rather foamy when compared to a plasma cell. The size of an osteoblast is 20-25 microns .
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21- Peripheral blood film from as case of Chronic Myeloid Leukemia marked leucocytosis showing the predominance of neutrophil precursors

2 pics
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20- Peripheral blood film showing neutrophilic shift to the left and presence of neutrophil toxic granulation.

2 pics
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19- Peripheral blood film showing increased numbers of Monoblasts and promonocytes (AML-M5)

4 pics
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18- Lymphoblast

3 pics

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17- Myeloblast blast

Size : large Cytoplasm : moderate Chromatin : fine Neucleoli : prominent Auer rods : present in 50%
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16- Degenerative changes in blood cell morphology with samples that are collected in EDTA

4 pics

Pictures show degenerating neutrophil with indistinct nuclear segmentation and many vacuoles and Erythrocytes are crenated.

Morphologyical changes In erythrocytes : erythrocytes began to show poikilocytosis with crenated forms and cytoplasmic spikes (burr cells, echinocytes) Morphological changes in granulocytes : include cytoplasmic rupture, loss of nuclear shape, elongation or indistinct segmentation of granulocyte nuclei, loss of chromatin definition (appear to have liquefied), pyknotic nuclei (necrobiotic forms), degranulation and cytoplasmic vacuolation... Blood film should be made within 5 hours of collection from blood anticoagulant with EDTA to avoid degenerative changes

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15- Peripheral blood smear of case of MDS/MPN showing:

1. Agranular neutrophil myelocyte

2. Eosinophil metamyelocyte

3. Two agranular neutrophil Metamyelocytes

4. 2 Two agranular neutrophils

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14-

1. Agranular Neutrophil Myelocyte

2. Eosinophil Myelocyte

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13- Peripheral blood smear of a case diagnosed as CLL showing increased number of mature-looking lymphocytes with presence of many smudge cells.

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12- Peripheral blood smear showing myeloblasts

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11- Plasma Cells

2 pics

Peripheral blood smear showing 2 plasma cells of round and oval shape with eccentric nuclei, basophilic cytoplasm and perinuclear halo

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10- Eosinophils

5 pics

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9- Picnotic Neutrophil

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8- Metamyelocyte with toxic granules

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7- Segmented Neutrophils with toxic granules

2 pics

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6- Hypersegmented Neutrophil

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5- Basophil

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4- Band Neutrophils with toxic granules

3 pics
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3- Hypersegmented Neutrophil

4 pics

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2- Small mature monotonus lymphocytes and smudge cells which are highly suggestive of CLL

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1- Leukocytosis, Neutrophilia , Shift to left , Mostly CML to confirmed by Philadelphia chromosome (other causes of leukomoid picture must be excluded)