Hematology Case 57
Hematology Case 57
Embedded Files
Patient Data
Patient Data
30 years old female.
Clinical Data
Clinical Data
Presented with fever.
Weight loss in the last month.
History of blood transfusion (2 units before 2 weeks)
Lymphadenopathy
Related Laboratory Results
Related Laboratory Results
CBC:
- WBC: 10.4x103 /uL (Analyzer differential count: Neutrophils: 0.8x103 /uL - Lymphocytes: 6.7x103 /uL - Monocytes: 2.8x103 /uL - Eosinophils: 0.1x103 /uL - Basophils: 0x103 /uL).
- HGB: 10.7g/dL - MCV: 95fL -MCH: 32pG - MCHC: 34%
- Platelet: 69x103 /uL
Peripheral blood smear : see below.
ESR: 124 mm/Hr
Normal RFT & LFT
Serum Iron: 34 umol/L (5-30.5)
Case Picture(s) / Photo(s)
Case Picture(s) / Photo(s)
Images Comment / Findings
Images Comment / Findings
Peripheral blood smear:
Differential cell count showed blast cells: 41% mostly of myeloblasts (Most of them are medium sized cells with high nuclear cytoplasmic ratio. Basophilic cytoplasm. Nucleus show open chromatin with 1-2 visible nucleoli)
Immunophenotyping Report (done in outside facility)
Immunophenotyping Report (done in outside facility)
Leukemia / Lymphoma panel
A population of cells which are morphologically and cytochemically correspond to blast cells with CD45 dim expression, gating shows blasts representin ~ 40% out of total peripheral blood cells.
The population are:
Positive for: CD34, CD38, CD13, CD117, CD33, HLA-DR & MPO
Negative for: CD19, CD2, CD7, CD20, CD64, CD11b, CD22, CD14, CD15 & cyCD3
Final Diagnosis
Final Diagnosis
A case of acute myeloid leukemia. Cytogenetic workup is recommended for further classification.
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