Hematology Case 14
Hematology Case 14
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Presented By Dr Mohammad Moharram
Released on 31-08-2019Patient Data
Patient Data
41 year old Male
Clinical Data
Clinical Data
History of disc prolapse 7 years ago on conservative treatment
Patient complains of severe back pain 3 days ago.
Patient has history of recurrent mild epistaxis related to sun exposure. Attacks always stops spontaneously. Last attack was 3 days ago.
Patient gave history of low platelet in previous routine investigations.
Related Laboratory Results
Related Laboratory Results
WBC: 10.4X10³/uL
HGB: 14.4 G/dL
MCV: 82.5 fL MCH: 26 PG
MCHC: 31.5 %
PLATELET: 41X10³/uL.
PT: 12.3 sec (INR: 1.04)
APTT: 29 (R.R.: 25-36)
Normal RFT, LFT and fasting Blood sugar
Platelet functions : Not available in our center.
Case Picture(s) / Photo(s)
Case Picture(s) / Photo(s)
Comment / Findings
Comment / Findings
Neutrophils show basophilic cytoplasmic inclusions ; resembling Dohle bodies. These inclusions are also seen in eosinophils and monocytes
Severe thrombocytopenia; giant platelets are frequantly seen.
Final Diagnosis
Final Diagnosis
Picture is highly suggestive of May-Hegglin anomaly (to be confirmed by molecular study: MYH9 gene mutation)
Additional Note
Additional Note
Patient refused admission. He left against medical advice (with consent)
This patient is a brother of the suspected May-Hegglin anomaly patient discussed in case No. 12 in this atlas.
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