Hematology Case 12
Hematology Case 12
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Presented By Dr Mohammad Moharram
Released on 01-05-2019Patient Data
Patient Data
46 year old Female
Clinical Data
Clinical Data
Recurrent Epistaxis (2 times ; Mild & controllable)
Mild to moderate thrombocytopenia in all previous CBC.
Clinician requested blood smear.
Related Laboratory Results
Related Laboratory Results
WBC: 4.2X10³/uL
HGB: 11.6 G/dL
MCV: 79 fL MCH: 23 PG
MCHC: 29.1 %
PLATELET: 55X10³/uL.
Bleeding time: 5 min.
PT: 11.5 sec (INR: 1)
APTT: 25 (R.R.: 25-36)
Normal RFT, LFT and fasting Blood sugar
Platelet functions : Not available in our center.
Provisional Diagnosis
Provisional Diagnosis
Platelet function disorder
Case Picture(s) / Photo(s)
Case Picture(s) / Photo(s)
Comment / Findings
Comment / Findings
Neutrophils show basophilic cytoplasmic inclusions ; resembling Dohle bodies.
Moderate thrombocytopenia; giant platelets are frequantly seen.
Mild microcytic hypochromic anemia with anisocytosis.
Final Diagnosis
Final Diagnosis
Picture is highly suggestive of May-Hegglin anomaly (to be confirmed by molecular study: MYH9 gene mutation)
Additional Note
Additional Note
Patient is advised to be referred to specialized center but she refused.
The case is associated with iron defeciency as confirmed by iron profile.
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