RBC Image Atlas

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25-Howell–Jolly bodies (RBC inclusion)

Image from a case of megaloblastic anemia due to severe vitamin B12 deficiency.Definition: Howell–Jolly bodies are typically round, smooth, and single, and represent nuclear remnants of dense chromatin. They are frequently found in smears of asplenic individuals or in megaloblastic anemia.

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24-RBCs morphological abnormalities

1- Dacrocyte2- Stomatocyte3- Polychromatic RBCs4- Ovalocyte

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23- Polychromatic RBCs

Polychromatic RBCs represents stained reticulocytes

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22- Macrocyte (Macrocytic RBCs)

Photos from a patient of megaloblastic anemia.Normal erythrocytes are approximately the same size as the nuclei of small lymphocytes, about 8 μm in diameter.

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21- RBC Basophilic Stippling

Photo 1 is from a patient of megaloblastic anemia.Photos 2,3 and 4 are from a patient of myeloproliferative disorder.

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20- Sickle Cell Solubility Test

Tube 1 : NegativeTube 2 : Positive"4 Photos for different cases"

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19- ECHINOCYTE (Burr Cell)

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18- Rouleaux formation of RBC

"2 Pics" from a known case of plasma cell myeloma

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17- Peripheral blood smear from a patient with sickle cell disease illustrates the spectrum of RBC findings including:

2 pics

1. sickle cells

2. Howell-Jolly bodies.

3. Polychromatophilic RBCs

4. Target cell

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16- Degenerative changes in blood cell morphology with samples that are collected in EDTA

4 Pictures show degenerating neutrophil with indistinct nuclear segmentation and many vacuoles and Erythrocytes are crenated.

Morphologyical changes In erythrocytes : erythrocytes began to show poikilocytosis with crenated forms and cytoplasmic spikes (burr cells, echinocytes) Morphological changes in granulocytes : include cytoplasmic rupture, loss of nuclear shape, elongation or indistinct segmentation of granulocyte nuclei, loss of chromatin definition (appear to have liquefied), pyknotic nuclei (necrobiotic forms), degranulation and cytoplasmic vacuolation... Blood film should be made within 5 hours of collection from blood anticoagulant with EDTA to avoid degenerative changes 

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15- Dacrocyte (Tear Drops)

"3 Photos"

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14-Bite Cells

"3 photos"

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13-Stomatocytes

"3 Photos"

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12- 

Golf ball inclusion 

Hemoglobin H Disease

BCB-stained PB smear 

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11- Polychromatic RBC (Red Arrow) 

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10- 

1. Macrocyte

2. Giant Platelet

3. Myeloblast  

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9- Dimorphic RBC "RBC Double Population"

UP: Microscopic pictures "3" DOWN: RBC Histogram for the same case 

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8- Rouleaux Formation

"2 Photos"

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7- PB film of a case of Beta-Thalassemia Major showing:

- dimorphic RBCs population (normo- and hypo-chromic) 

- nRBCs

- Fragmented RBCs 

- Microspherocytes

- Target cells

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6-

1. Echinocytes/Burr RBC

2. Basophilic Stippling

3. Microspherocyte

4. Elliptocyte (cigar-shaped) RBC

5. Polychromatic Ovalocytes

6. Tear-drop RBCs (Dacrocytes)

7. Elliptocyte (cigar-shaped) RBC  

8. Ovalocytes

9. Polychromatic Ovalocytes

10. Schistocytes (Fragmented RBCs) 

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5- Target Cells

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4- Hereditary Elliptocytosis

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1- Howel Jolly Body

2- Schistocyte

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2- Sickle Cell

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1-

1. Target Cell

2. Sickle Cell